105629q Vapor phase thermolysis of 1-hexen-5-yn-3-ol. An acetylenic oxy- Cope reaction. Viola, Alfred; MacMillan, John H. (Northeastern Univ., Boston, Mass.). J. Amer. Chem. Soc., 1968, 90(22), 6141-5 (Eng).

1-Hexen-5-yn-3-ol, shown to be free of the internal acetylenic isomer, was subjected to vapor phase thermolysis in a flow system over the range of 350-390 degrees and under various pressures. The extent of beta-hydroxyolefin cleavage, which leads to formation of acrolein and allene, was independent of residence time in the thermolysis zone but increased with temperature, indicative of a higher activation energy than the competing rearrangement processes. One of these processes affords 4,5-hexadienal via an acetylenic analog of the oxy-Cope reaction. Also produced is 3-cyclopentenecarboxaldehyde in amounts increasing with increasing temperature and/or increasing residence time. The data is consistent with an electrocyclic reaction involving the enol progenitor of the Cope product, which ketonizes only upon condensation in the product trap. RCJC

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